Synthesis, Spectral Characterization and Antimicrobial Activity of Novel Hetarylazoindole Dyes from Some 2-Aminobenzothiazole Derivatives

Yahyazadeh, A.; Yousefi, H.; Nezhademehdipour, Z.

Synthesis, Spectral Characterization and Antimicrobial Activity of Novel Hetarylazoindole Dyes from Some 2-Aminobenzothiazole Derivatives

Authors

Department of Chemistry, University of Guilan

Abstract

In this study four heteroaryl amines have been prepared from the reaction of aniline derivatives, potassium thiocyanate and bromine in acetic acid. Coupling of diazonium salts of corresponding amines with 2-methylindole led to hetaryl-azoindole dyes. These dyes have been characterized by UV–Visible, FT-IR and 1H NMR spectroscopy. The solvatochromism properties of dyes have been investigated in various solvents. In addition, the antimicrobial activity of the synthesized dyes has been evaluated against Escherichia coli, Bacillus subtilis, Micrococcus leuteus and Pseudomonas aeruginosa bacterial strains. The results showed that some of these dyes are potential antibacterial compounds.

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