1
Department of Nutrition, University of Medical Sciences Urmia
2
Department of Organic Colorants, Institute for Color Science and Technology
3
Department of Clinical Biochemistry, Tarbiat Modarres University
Abstract
Carcinogenic and mutagenic potential of some azo dyes as a category of common dyes in different types of industries has been reported. Current study was designed to asses the DNA damage induced by some commonly used commercial grade acid azo dyes using single cell electrophoresis, comet assay, in human HL-60 cell lines. The results showed that DNA damage in HL-60 cells, namely comet positive cells, were not significantly increased after 12 and 24 hours treatment with azo dyes: Acid Red 14, Acid Blue 92, Acid Blue 5 and Acid Yellow 36 at concentration ranging 0.1- 1.2%. Considering complex metabolic mechanisms of azo dyes in mammalians, further evaluation of DNA damage using in vivo comet assay is suggested.
Salami, S., Nourmohammadian, F., & Aghaei, M. (2007). Assessment of Acid Azo Dyes-induced DNA Damage Using Single Cell Electrophoresis. Journal of Color Science and Technology, 1(2), 111-119.
MLA
S. Salami; F. Nourmohammadian; M. Aghaei. "Assessment of Acid Azo Dyes-induced DNA Damage Using Single Cell Electrophoresis", Journal of Color Science and Technology, 1, 2, 2007, 111-119.
HARVARD
Salami, S., Nourmohammadian, F., Aghaei, M. (2007). 'Assessment of Acid Azo Dyes-induced DNA Damage Using Single Cell Electrophoresis', Journal of Color Science and Technology, 1(2), pp. 111-119.
VANCOUVER
Salami, S., Nourmohammadian, F., Aghaei, M. Assessment of Acid Azo Dyes-induced DNA Damage Using Single Cell Electrophoresis. Journal of Color Science and Technology, 2007; 1(2): 111-119.
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